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Classification of ginsenosides

New promising anti-cancer drug candidate (aglycon dammarane sapogenin AGS) discovered
2007年1月3日:中科院上海營養科學研究所張瑞穩、王慧與瀋陽藥科大學教授趙餘慶通過合作研究後發現:從人參果和三七中提取到多種治療癌症的有效成分- 達瑪烷苷元,接近於理想抗癌藥物。目前,相關研究成果已分別發表於國際科學期刊《醫用化學》和《癌症化療與藥理學》上。 作為中國傳統中藥的人參曾被用於多種中醫驗方。現代醫學研究表明,人參皂苷作為人參中一類主要的有效成分,具有抗腫瘤活性,尤其是無糖化的達瑪烷苷元,其抗癌活性大大增加,接近於常見的化療藥物,但其副作用卻比化療藥小很多。非正式臨床觀測顯示:人參...
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Ginsenosides are main active ingredients in Asian ginseng and American ginseng.

To date, more than 40 ginsenosides are found. Ginsenosides are denoted by -RX (note: X=0、a1、a2、a3、b1、b2、b3、c、d、e、f、g1、g2、g3、h1、h2、h3、s1、s2). In addition, F11 belongs to pseudoginsenoside saponin.

According to their mother ring structure, ginsenosides can be classified into 3 types:

  • oleanolic acid type
  • dammarane type
  • Ocotillol type

Dammarane type saponins account for 70% of total saponins in ginseng, and it can be further categorized into protopanaxadiol-type and protopanaxatriol-type, their mother ring structures are listed below.

PPD

PPT

Chemical processing or hydrolysis in GI tract will convert above two types of ginsenosides into aglycone protopanaxadiol (PPD) and protopanaxatriol (PPT).

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