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Research Frontiers
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Pharmacological Review of Ginsenoside Dammarane Saponin Rh2



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Pharmacological Review of Ginsenoside Dammarane Saponin Rg1



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Pharmacological Review of Ginsenoside Dammarane Saponin Rb1



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Pharmacological Review of Aglycon Dammarane Sapogenin (AGS) – Protopanaxatriol (PPT)



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Pharmacological Review of Aglycon Dammarane Sapogenin (AGS) – Protopanaxadiol (PPD)


 

Classification of ginsenosides

Rh2 improves insulin sensitivity
Ginsenoside Rh2, one of the ginsenosides contained in the Panax ginseng root, was employed to screen the effect on insulin resistance of rats induced by a diet containing 60% fructose. Single intravenous injection of ginsenoside Rh2 decreased the pl...
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Ginsenosides are main active ingredients in Asian ginseng and American ginseng.

To date, more than 40 ginsenosides are found. Ginsenosides are denoted by -RX (note: X=0、a1、a2、a3、b1、b2、b3、c、d、e、f、g1、g2、g3、h1、h2、h3、s1、s2). In addition, F11 belongs to pseudoginsenoside saponin.

According to their mother ring structure, ginsenosides can be classified into 3 types:

  • oleanolic acid type
  • dammarane type
  • Ocotillol type

Dammarane type saponins account for 70% of total saponins in ginseng, and it can be further categorized into protopanaxadiol-type and protopanaxatriol-type, their mother ring structures are listed below.

PPD

PPT

Chemical processing or hydrolysis in GI tract will convert above two types of ginsenosides into aglycone protopanaxadiol (PPD) and protopanaxatriol (PPT).

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