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Brief review of Asian ginseng pharmacology

Classification of ginsenosides
Ginsenosides are main active ingredients in Asian ginseng and American ginseng. To date, more than 40 ginsenosides are found. Ginsenosides are denoted by -RX (note: X=0、a1、a2、a3、b1、b2、b3、c、d、e、f、g1、g2、g3、h1、h2、h3、s1、s2). In addition, F11 belongs to ...
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Central nervous system

  • Asian ginseng (ginseng in brief) can regulate the excitatory and inhibitory processes in the central nervous system, but the excitatory activity takes prodominance.
  • Ginseng in apropriate doses can improve the learning and memory ability.
  • Ginseng also reduces fatigue after exercise, partially due to its stimulation on lipid mobilization, protein and RNA synthesis.
  • Ginseng has intrinsic cholinomimetic and catacholamine-mimetic activity, and can enhance functions of choline system.
  • Ginseng promotes synthesis of proteins, RNA and DNA.
  • Ginseng protects the brain from ischemia and reperfusion injury.

Improve the adaptability of the body

  • As a adaptogen, ginseng changes the responsiveness of the body towards various harmful stimuli and stresses.

Cardiovascular system

  • Cardiac function: low-dose ginseng stimulates cardiac muscle to increase cardiac output and rate, however, high-dose ginseng suppresses the heart contraction and rate instead.
  • Myocardial protection: ginseng improves the resistance of cardiac muscle towards ischemia, and reduces injuries due to ischemia and reperfusion.
  • Vasoactive activity: ginseng can dilate blood vessels, though its vasorestrictive action was documented; therefore, both reduction and increase of blood pressure are reported.
  • Increase resistance to anoxia: ginseng increases the survival time of animals under anoxia environment.
  • Hematopoiesis: ginseng stimulates bone marrow to produce blood cells.
  • Blood thinning effect: ginseng inhibits platelet aggregation.
  • Lipid-lowering and anti-atherosclerosis: ginseng reduces blood levels of cholesterol, triglycerides, and LDL, but increases HDL.

Anti-Shock

  • Ginseng not only alleviates symptoms of anaphylactic shock, but also improve hypovolumic shock secondary to fluid or blood loss.

Effect on the Liver

  • Ginseng increases the activity of transforming enzymes in the liver and therefore enhances the detoxification capability of the liver.

Endocrine system

  • Ginseng stimulates pituitary-adrenal system and then incrases the level of corcoticosteroids
  • Ginseng can stimulate sexual glands in both male and female. Ginseng increases testosterone level.

Hypoglycemic action

  • Ginseng restores insulin receptor sensitivity and reduces blood glucose level.
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